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Serigne Mor Samb Gueye
Department of Animal Biology, Cheikh Anta Diop University of Dakar, Dakar, SenegalPublications
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Research Article
Chemotherapy Resistance and Breast Cancer in Senegal: MDR1 Gene Polymorphism Running Head: MDR1 Gene Polymorphism in Breast Cancer
Author(s): Serigne Mor Samb Gueye, Fatimata Mbaye*, Mouhamadou Mansour SY and Mbacke Sembene
Objective: Interindividual variability in the pharmacokinetics of anticancer drugs limits their clinical use. The polymorphisms of MDR1 gene may explain these Interindividual variations and are associated with a phenotypic variation in P-glycoprotein, a membrane efflux pump that eliminates anthracyclines. This study aimed to investigate the role of two polymorphisms, C1236T and C3435T, in exons 12 and 26 of MDR1 gene in Senegalese patients with breast cancer who were treated with neoadjuvant chemotherapy with anthracyclines with fluorouracil-adriamycin-cyclophosphamide or doxorubicin-cyclophosphamide AC protocols. Methods: PCR-RFLP was used to identify different genotypes of the C1236T and C3435T polymorphisms. Here, we evaluated five clinico-pathological parameters (age, number of therapy cures, histology,.. Read More»