Serena McCalla

Publications

• Research Article   
  Potential microRNA Biomarker Panel for Predicting Evolution of Pancreatitis to Pancreatic Ductal Adenocarcinoma
  Author(s): Mira Nuthakki*, Vivian Utti and Serena McCalla
  
  Purpose: Pancreatitis is one of the most important risk factors for Pancreatic Ductal Adeno Carcinoma (PDAC). PDAC is a silent, aggressive malignancy that has less than 5% survival rate at 5 years. Detection at early stage and resection of PDAC significantly improves survival. A differentially expressed microRNA panel was sought that could predict the risk of progression to PDAC from pancreatitis. Methods: Differentially Expressed microRNA (DEM) in serum that was common between pancreatitis and PDAC were extracted from two microarray Genomic Spatial Event (GSE) datasets containing pancreatitis, PDAC, and control samples. Eight groups of DEM were derived from multiple bioinformatics methods such as differential expression, miRNA interaction networks, target gene prediction tools, functional enrichment analysis, and machine learning models. Th.. Read More»
  

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