Rohan Jayasinghe

Publications

• Review   
  Distinguishing Therapeutic Hypoxia from Pathogenic Hypoxia: Benefits for Cardiac Patients
  Author(s): Kieran Oldfield, Rohan Jayasinghe and Gillian Renshaw*
  
  Therapeutic intermittent hypoxia is a non-pharmacological lab-based intervention with the demonstrated benefits of ascent to moderate altitude. Depending on the dose or severity of therapeutic intermittent hypoxia or high-altitude, hypoxic exposure can stabilise master gene regulators to instigate beneficial adaptations. Therapeutic intermittent hypoxia has been demonstrated to initiate adaptive phenotypic changes such as: decreased sympathetic input with a decrease in systolic blood pressure; increased haemoglobin and red blood cell count; altered substrate metabolism to favour increased glucose uptake and fatty acid metabolism with decreased fatty acid synthesis; increased antioxidant defence; decreased inflammatory cytokines. Such beneficial adaptive changes to therapeutic intermittent hypoxia serve not only to diminish the impact of cardiovascular pat.. Read More»
  

  Abstract HTML PDF