Total antioxidant status in newly-diagnosed type II diabetes patients in Bangladeshi population

Abstract

Muhammad Abdul Hai Siddique, Zinat Tamannaa, Syed Muhammad Kamaluddin, Muhammad Saiedullah, Muhammad Aminul Haque Khan, Matiar Rahman, Liaquat Ali

Background: Prevalence and complications of type 2 diabetes mellitus (DM) is increasing in Bangladeshi population. Oxidative stress plays an important role in the pathogenesis of DM and its complications. However, antioxidant status and its contribution to type 2 DM are less explored in Bangladeshi population. Aim: The aim of this study was to evaluate antioxidant status (TAS) in newly diagnosed never treated type 2 diabetic subjects against apparently healthy nondiabetic subjects of Bangladeshi origin. Methods: In this cross-sectional study, 179 adult subjects were included. Fasting and postprandial blood specimens were collected and plasma glucose concentrations were measured by standard methods. Fasting plasma total antioxidant capacity (TAC) was measured by ferric reducing ability of plasma (FRAP) assay and compared among diabetic, prediabetic and nondiabetic. Results: TAC was 1077±217 µmol/L, 1225 ±285 µmol/L and 1425±319 µmol/L in diabetic (n=79), prediabetic (n=42) and nondiabetic (n=58) subjects respectively. TAS in diabetic subjects was 148 µmol/L lower than that of prediabetic subjects (p<0.05) and 348 µmol/L lower than that of nondiabetic subjects (p<0.001) whereas it was 200 µmol/L lower in prediabetic subjects compared to nondiabetic subjects (P<0.01). Conclusion: It may be concluded that total antioxidant status is lower in type 2 diabetic subjects compared to nondiabetic subjects and it may be related to the pathogenesis of T2DM in the studied population.