Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats

Abstract

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu

Background/Aim: The effects of several household materials containing toxic chemicals have been a focus point in recent studies concerning male infertility. In this study, we evaluated the testiculotoxic effect of isopropyl alcohol-based air freshener (IBA) on the testis of adult Wistar rats. Materials and Methods: About 20 adult Wistar rats were divided at random, to four groups, five in each group. Group A rats were exposed to natural air for 4 weeks. The study groups (B, C, and D) were exposed to different graded doses of IBA for 4 weeks. Group B rats were exposed to 2.5 ml, Group C to 5 ml, and Group D to 10 ml of IBA for 6 h/day via whole body inhalation. Results: The results of the study showed a statistically significant (P < 0.05) decrease in testis weight, testis relative body weight and testis volume in the IBA exposed groups as compared to the control group. Reduction in sperm concentration, sperm motility, normal sperm morphology and significant (P < 0.05) increase in abnormal sperm morphology was observed in the study groups when compared to that of the control group. Furthermore, in comparison to the control group, degeneration of testicular architecture was observed in the study groups. Conclusion: Exposure of IBA to adult Wistar rats causes testicular histology damage and deranged sperm parameters.