Ethno-medicinal studies of Brachystegia eurycoma Harms, Detarium microcarpum Guill. & Perr and Mucuna pruriens (L.) DC on Blood Glucose Levels, Liver Enzymes, and Lipid Profile of Female Wistar Rats

Abstract

Godspower I. Onyeso, Kpobari W. Nkpaa, Uche P Wigwe

Aim: This study was designed to investigate the ethno-medicinal effect of Brachystegia eurycoma Harms (B. eurycoma), Detarium microcarpum Guill. & Perr (D. microcarpum) and Mucuna pruriens (L.) DC (M. pruriens) seeds on blood glucose levels, liver enzymes, and lipid profile of female Wistar rats. Materials and Methods: B. eurycoma, D. microcarpum and M. pruriens aqueousseeds extract were administered at a single dose of 200 mgkg-1 body weight to the experimental animals individually and in combination daily for three weeks. Results: The blood glucose level in group II, IV and V (94.5±3.09, 99.5±3.77 and 100.0±5.83 mg dL-1) were significant different (p0.05) compare to the control. AST and ALT level in group II and III were also significant different (p<0.05) when compared to group I and V. However, group IV was significant higher (p<0.05) when compared to group II, III and V. Conclusions: This present study showed that administration of B. eurycoma, D. microcarpum and M. pruriens seeds extract at 200 mgkg-1 alone or in combination improved blood glucose level, liver function profile, liver enzymes, pancreas and did not posed any significant health risk. In conclusion, B. eurycoma, D. microcarpum and M. pruriens may be safe for use as a soup thickener.