Circulating Resistin Concentration Associates Strongly with Post-prandial Plasma Glucose in Newly Diagnosed Bangladeshi Type 2 Diabetic Patients

Abstract

Syed Muhammad Kamaluddin, Muhammad Saiedullah, Shahangir Biswas , Shoma Hayat, Sharif Akhteruzzaman , Omar Faruque, Liaquat Ali

Background and Aim: Adipocytokine, resistin, has proposed link with obesity-related insulin resistance (IR) and type 2 diabetes mellitus. This study aims to evaluate serum resistin in newly diagnosed T2DM subjects with different body mass index (BMI) groups. Subjects and Methods: A total of 147 newly diagnosed T2DM subjects were recruited in this study. Anthropometric indices were measured using standard techniques. Insulin and resistin were measured by enzyme-linked immunosorbent assay method. Insulin secretory capacity homeostasis model assessment (HOMA) beta and insulin sensitivity (HOMA%S) were calculated using fasting glucose and insulin by HOMA-CIGMA software. SPSS for windows was used for statistical analysis. Results: The subjects were divided into three groups on the basis of BMI cut-off points suggested by WHO for the Asian population (Group 1: BMI 18.5-23, Group 2: BMI 23.1-27.5, Group 3: BMI >27.5). Resistin was significantly higher in Group 3 compared with Group 1 and Group 2. HOMA%S was significantly lower in Group 3 compared to Group 1 and Group 2. When the subjects were categorized in three tertiles according to resistin values, HOMA%S was significantly lower in 3rd tertile compared to 1st tertile. In multiple linear regression analysis, both BMI and post-prandial serum glucose were significantly associated with serum resistin level, but that of the latter one was stronger. Conclusions: (a) BMI positively and insulin sensitivity inversely associates with serum resistin concentration, and (b) post-prandial hyperglycemia shows a positive and independent association with serum resistin.