ISSN 2146-832X
 

Original Research 


Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius)

Jibril Zuberu, Malajiya IA Saleh, Abdul W. Alhassan, Munira Aliyu, Bello Y Adamu, Bilkisu T Iliya.

Abstract
Background: Hyperlipidemia can result in deleterious effect both on the cardiovascular and renal systems. The therapeutic values of camel milk have been established by several studies making it suitable for metabolic diseases. This study was designed to investigate the effect of poloxamer 407-induced hyperlipidemia on serum electrolyte, urea, creatinine, cardiorenal histomorphological changes of Wistar rats and the functional role of oral administration of camel milk. Materials and Methods: Twenty adult male Wistar rats weighing between 150 and 200 g were randomly assigned into four groups of five animals each; group I was administered distilled water, group II was induced with poloxamer 407 (P407), group III was induced with P407 and treated with atorvastatin (20 mg/kg), and group IV was induced with P407 and treated with camel milk 250 mg/kg. After 21 days, serum samples, renal and heart tissues were collected for the determination of urea, creatinine, and histomorphological changes, respectively. Results: Poloxamers 407-induced hyperlipidemia resulted in significant increases in serum bicarbonate and urea level, glomerulotubular and myocardiac necrosis, aortic adipocytes, and renal lymphocytes infiltration. Co-administration of camel milk significantly decreased serum urea and bicarbonate along with protection of cardiorenal tissue integrity. Conclusions: The results of our findings show that poloxamer 407-induced hyperlipidemia in Wistar rats can progress to alteration of electrolyte balance as well as cardiorenal tissues distortion. Co-administration of camel milk protects against cardiac and renal dysfunction in P407-induced hyperlipidemic Wistar rats.

Key words: Poloxamer 407, camel milk, hyperlipidemia, histomorphology


 
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Pubmed Style

Zuberu J, Saleh MI, Alhassan AW, Aliyu M, Adamu BY, Iliya BT. Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius). J Mol Pathophysiol. 2018; 7(1): 7-17. doi:10.5455/jmp.20180830041332


Web Style

Zuberu J, Saleh MI, Alhassan AW, Aliyu M, Adamu BY, Iliya BT. Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius). http://www.jmolpat.com/?mno=5926 [Access: December 13, 2018]. doi:10.5455/jmp.20180830041332


AMA (American Medical Association) Style

Zuberu J, Saleh MI, Alhassan AW, Aliyu M, Adamu BY, Iliya BT. Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius). J Mol Pathophysiol. 2018; 7(1): 7-17. doi:10.5455/jmp.20180830041332



Vancouver/ICMJE Style

Zuberu J, Saleh MI, Alhassan AW, Aliyu M, Adamu BY, Iliya BT. Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius). J Mol Pathophysiol. (2018), [cited December 13, 2018]; 7(1): 7-17. doi:10.5455/jmp.20180830041332



Harvard Style

Zuberu, J., Saleh, . M. I., Alhassan, . A. W., Aliyu, . M., Adamu, . B. Y. & Iliya, . B. T. (2018) Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius). J Mol Pathophysiol, 7 (1), 7-17. doi:10.5455/jmp.20180830041332



Turabian Style

Zuberu, Jibril, Malajiya IA Saleh, Abdul W. Alhassan, Munira Aliyu, Bello Y Adamu, and Bilkisu T Iliya. 2018. Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius). Journal of Molecular Pathophysiology, 7 (1), 7-17. doi:10.5455/jmp.20180830041332



Chicago Style

Zuberu, Jibril, Malajiya IA Saleh, Abdul W. Alhassan, Munira Aliyu, Bello Y Adamu, and Bilkisu T Iliya. "Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius)." Journal of Molecular Pathophysiology 7 (2018), 7-17. doi:10.5455/jmp.20180830041332



MLA (The Modern Language Association) Style

Zuberu, Jibril, Malajiya IA Saleh, Abdul W. Alhassan, Munira Aliyu, Bello Y Adamu, and Bilkisu T Iliya. "Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius)." Journal of Molecular Pathophysiology 7.1 (2018), 7-17. Print. doi:10.5455/jmp.20180830041332



APA (American Psychological Association) Style

Zuberu, J., Saleh, . M. I., Alhassan, . A. W., Aliyu, . M., Adamu, . B. Y. & Iliya, . B. T. (2018) Electrolytes metabolism and cardio-renal histomorphological derangements of an experimental model of hyperlipidemia: Functional role of camel milk (Camelus dromedarius). Journal of Molecular Pathophysiology, 7 (1), 7-17. doi:10.5455/jmp.20180830041332





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