ISSN 2146-832X
 

Original Research 


Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu.

Abstract
Background/Aim: The effects of several household materials containing toxic chemicals have been a focus point in recent studies concerning male infertility. In this study, we evaluated the testiculotoxic effect of isopropyl alcohol-based air freshener (IBA) on the testis of adult wistar rats.
Materials and Methods: Twenty adult wistar rats were divided at random, to four groups, five in each group. Group A rats were exposed to natural air for 4 weeks. The study groups (B, C and D) were exposed to different graded doses of IBA for 4 weeks. Group B rats were exposed to 2.5ml, group C to 5ml and group D to 10 ml of IBA for 6hrs/day via whole body inhalation. Results: The results of the study showed a statistically significant (p<0.05) decrease in testis weight, testis relative body weight and testis volume in the IBA exposed groups as compared to the control group. Reduction in sperm concentration, sperm motility, normal sperm morphology and significant (p<0.05) increase in abnormal sperm morphology was observed in the study groups when compared to that of the control group. Also, in comparison to the control group, degeneration of testicular architecture was observed in the study groups.
Conclusion: exposure of IBA to adult wistar rats causes testicular histology damage, and deranged sperm parameters.

Key words: Testiculotoxicity, IBA, testicular architecture, Inhalation, Sperm parameter, testis, wistar rats


 
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Pubmed Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu. Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats. J Mol Pathophysiol. 2017; 6(2): 17-23. doi:10.5455/jmp.20170415095238


Web Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu. Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats. http://www.jmolpat.com/?mno=254979 [Access: January 24, 2019]. doi:10.5455/jmp.20170415095238


AMA (American Medical Association) Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu. Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats. J Mol Pathophysiol. 2017; 6(2): 17-23. doi:10.5455/jmp.20170415095238



Vancouver/ICMJE Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu. Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats. J Mol Pathophysiol. (2017), [cited January 24, 2019]; 6(2): 17-23. doi:10.5455/jmp.20170415095238



Harvard Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu (2017) Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats. J Mol Pathophysiol, 6 (2), 17-23. doi:10.5455/jmp.20170415095238



Turabian Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu. 2017. Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats. Journal of Molecular Pathophysiology, 6 (2), 17-23. doi:10.5455/jmp.20170415095238



Chicago Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu. "Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats." Journal of Molecular Pathophysiology 6 (2017), 17-23. doi:10.5455/jmp.20170415095238



MLA (The Modern Language Association) Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu. "Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats." Journal of Molecular Pathophysiology 6.2 (2017), 17-23. Print. doi:10.5455/jmp.20170415095238



APA (American Psychological Association) Style

Adebanji Modupe Akingbade, Abdulfatai Olakunle Ojewale, Akihoromotei Idhirhi, Oluwaseun Ruth Olasehinde, Oluwaseun Babatunde Ibitoye, Stephen okikioluwa Adeyelu (2017) Testiculotoxicity activities of Isopropyl Alcohol-based Air Freshener on the Testis of Adult Wistar Rats. Journal of Molecular Pathophysiology, 6 (2), 17-23. doi:10.5455/jmp.20170415095238





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