ISSN 2146-832X
 

Original Research 


Oxidative stress in acne vulgaris: an important therapeutic target

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif.

Cited by (1)

Abstract
Objective: There has been an increasing focus on the extent to which oxidative stress is involved in the pathophysiology of acne. The aim of this study is to investigate the existence of oxidative stress and inflammatory marker IL-8 in patients with acne vulgaris, and the role of oxidative stress as a therapeutic target in the treatment of acne vulgaris.
Methods: A randomized prospective clinical trial was carried out on 56 patients of both sexes with age range of 14-35 years who attend to outpatient clinic in Al-Hussein Teaching Hospital-Kerbalaa -Iraq over a period from December 2011 to May 2012, all patients examined clinically by dermatologist and classified according to disease severity. Serum levels of Glutathione (GSH), Malondialdehyde (MDA) and Interleukine -8 (IL-8) in the acne patients were measured by using ready- for- use Elisa kits, and compared to that of 28 healthy volunteers.
Results: The results of the serum level analysis of MDA for the acne patients (expressed as the mean± Standard deviation) was highly significant (P value ≤ 0.001) higher than that of healthy volunteers, while serum level of GSH was highly significant (P value ≤ 0.001) lower in acne patients compared to healthy volunteers; there is a significant difference (P value ≤ 0.05) found in serum levels of IL-8 between the acne patients and the healthy volunteers.
Conclusions: The results obtained in this study clearly showed the existence of oxidative stress in patients with acne vulgaris, and that oxidative stress along with inflammation play a critical role in acne pathogenesis; furthermore, oxidative stress in acne patients may represents a potential therapeutic target and interference with antioxidant is a rationale choice.

Key words: Acne vulgaris; Inflammation; Oxidative stress


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ahmed Salih Sahib
Articles by Haidar Hamid Al-Anbari
Articles by Ahmed R. Abu Raghif
on Google
on Google Scholar
Article Statistics
 Viewed: 4357
Downloaded: 1070
Cited: 1

REFERENCES
1. Adityan B, Kumari R, Thappa DM. Scoring systems in acne vulgaris. Indian J Dermatol Venereol Leprol 2009; 75:323-6. [DOI via Crossref]    [Pubmed]   
2. Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet 2012; 379:361-72. [DOI via Crossref]   
3. Jappe U. Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy. Acta Derm Venereol 2003; 83:241-8. [DOI via Crossref]    [Pubmed]   
4. Katzman M, Logan AC. Acne vulgaris: nutritional factors may be influencing psychological sequelae. Med Hypotheses. 2007; 69:1080-4. [DOI via Crossref]    [Pubmed]   
5. Kurokawa I, Danby FW, Ju Q, Wang X, Xiang LF, Xia L, Chen W, Nagy I, Picardo M, Suh DH, Ganceviciene R, Schagen S, Tsatsou F, Zouboulis CC: New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009; 18:821-32. [DOI via Crossref]    [Pubmed]   
6. Jeremy AH, Holland DB, Roberts SG, Thomson KF, Cunliffe WJ. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003; 121:20-7. [DOI via Crossref]    [Pubmed]   
7. Sarici G, Cinar S, Armutcu F, Altinyazar C, Koca R, Tekin NS. Oxidative stress in acne vulgaris. J Eur Acad Dermatol Venereol 2010; 24:763-7. [DOI via Crossref]    [Pubmed]   
8. Chiba K, Yoshizawa K, Makino I, Kawakami K, Onoue M. Changes in the levels of glutathione after cellular and cutaneous damage induced by squalene monohydroperoxide. J Biochem Mol Toxicol 2001; 15:150-8. [DOI via Crossref]    [Pubmed]   
9. Portugal M, Barak V, Ginsburg I, Kohen R. Interplay among oxidants, antioxidants, and cytokines in skin disorders: present status and future considerations. Biomed Pharmacother 2007; 61:412-22. [DOI via Crossref]    [Pubmed]   
10. Richie JP Jr, Skowronski L, Abraham P, Leutzinger Y. Blood glutathione concentrations in a large-scale human study. Clin Chem 1996; 42:64-70. [Pubmed]   
11. Steghens JP, van Kappel AL, Denis I, Collombel C. Diaminonaphtalene, a new highly specific reagent for HPLC-UV measurement of total and free malondialdehyde in human plasma or serum. Free Radic Biol Med 2001; 31:242-9. [DOI via Crossref]   
12. Brown KJ. A novel in vitro assay for human IL-8 angiogenesis. Laboratory Investigation 1996; 75:539-55. [Pubmed]   
13. Lee DJ, Van Dyke GS, Kim J. Update on pathogenesis and treatment of acne. Curr Opin Pediatr 2003; 15:405-10. [DOI via Crossref]    [Pubmed]   
14. Bhambri S, Del Rosso JQ, Bhambri A. Pathogenesis of acne vulgaris: recent advances. J Drugs Dermatol 2009; 8:615-8. [Pubmed]   
15. Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol 2012; 11:742-6. [Pubmed]   
16. Basak PY, Gultekin F, Kilinc I. The role of the antioxidative defense system in papulopustular acne. J Dermatol 2001; 28:123-7. [Pubmed]   
17. Basak PY, Gultekin F, Kilinc I, Delibas N. The effect of benzoyl peroxide and benzoyl peroxide/erythromycin combination on the antioxidative defence system in papulopustular acne. Eur J Dermatol 2002; 12:53-7. [Pubmed]   
18. Abdel Fattah NS, Shaheen MA, Ebrahim AA, El Okda ES. Tissue and blood superoxide dismutase activities and malondialdehyde levels in different clinical severities of acne vulgaris. Br J Dermatol 2008; 159:1086-91. [Pubmed]   
19. Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipids Health Dis 2010; 9:141. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
20. Ikeno H, Tochio T, Tanaka H, Nakata S. Decrease in glutathione may be involved in pathogenesis of acne vulgaris. J Cosmet Dermatol 2011; 10:240-4. [DOI via Crossref]    [Pubmed]   
21. Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new? J Eur Acad Dermatol Venereol 2003; 17:663-9. [DOI via Crossref]   
22. Akamatsu H, Horio T, Hattori K. Increased hydrogen peroxide generation by neutrophils from patients with acne inflammation. Int J Dermatol 2003; 42:366-9. [DOI via Crossref]    [Pubmed]   
23. Ottaviani M, Alestas T, Flori E, Mastrofrancesco A, Zouboulis CC, Picardo M. Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris. J Invest Dermatol 2006; 126:2430-7. [DOI via Crossref]    [Pubmed]   
24. Zouboulis CC. Zileuton, a new efficient and safe systemic anti-acne drug. Dermatoendocrinol 2009; 1:188-92. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
25. Zouboulis CC, Seltmann H, Alestas T. Zileuton prevents the activation of the leukotriene pathway and reduces sebaceous lipogenesis. Exp Dermatol 2010; 19:148-50. [DOI via Crossref]    [Pubmed]   
26. Grange PA, Chéreau C, Raingeaud J, Nicco C, Weill B, Dupin N, Batteux F. Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin. PLoS Pathog 2009; 5(7):e1000527. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
27. Arican O, Kurutas EB, Sasmaz S. Oxidative stress in patients with acne vulgaris. Mediators Inflamm 2005; 2005(6):380-4. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

This Article Cited By the following articles

Evaluation of anti-acne properties of phloretinin vitroandin vivo
Int J Cosmet Sci 2016; 38(1): 85.

1
 
How to Cite this Article
Pubmed Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif. Oxidative stress in acne vulgaris: an important therapeutic target. J Mol Pathophysiol. 2013; 2(1): 27-31. doi:10.5455/jmp.20130127102901


Web Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif. Oxidative stress in acne vulgaris: an important therapeutic target. http://www.jmolpat.com/?mno=24732 [Access: December 13, 2018]. doi:10.5455/jmp.20130127102901


AMA (American Medical Association) Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif. Oxidative stress in acne vulgaris: an important therapeutic target. J Mol Pathophysiol. 2013; 2(1): 27-31. doi:10.5455/jmp.20130127102901



Vancouver/ICMJE Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif. Oxidative stress in acne vulgaris: an important therapeutic target. J Mol Pathophysiol. (2013), [cited December 13, 2018]; 2(1): 27-31. doi:10.5455/jmp.20130127102901



Harvard Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif (2013) Oxidative stress in acne vulgaris: an important therapeutic target. J Mol Pathophysiol, 2 (1), 27-31. doi:10.5455/jmp.20130127102901



Turabian Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif. 2013. Oxidative stress in acne vulgaris: an important therapeutic target. Journal of Molecular Pathophysiology, 2 (1), 27-31. doi:10.5455/jmp.20130127102901



Chicago Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif. "Oxidative stress in acne vulgaris: an important therapeutic target." Journal of Molecular Pathophysiology 2 (2013), 27-31. doi:10.5455/jmp.20130127102901



MLA (The Modern Language Association) Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif. "Oxidative stress in acne vulgaris: an important therapeutic target." Journal of Molecular Pathophysiology 2.1 (2013), 27-31. Print. doi:10.5455/jmp.20130127102901



APA (American Psychological Association) Style

Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif (2013) Oxidative stress in acne vulgaris: an important therapeutic target. Journal of Molecular Pathophysiology, 2 (1), 27-31. doi:10.5455/jmp.20130127102901





Most Viewed Articles
  • Prevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis
    Ertan Altaylı, Ercan Malkoc, Bilal Fırat Alp, Ahmet Korkmaz
    J Mol Pathophysiol. 2012; 1(1): 53-62
    » Abstract & References » doi: 10.5455/jmp.20120321060902

  • Therapeutic potential of metals in managing diabetes mellitus: a review
    Geeta Pandey, Gyan Chand Jain, Nidhi Mathur
    J Mol Pathophysiol. 2012; 1(1): 63-76
    » Abstract & References » doi: 10.5455/jmp.20120410105457

  • Modulation of glucose and lipid metabolism in adrenalectomised rats given glycyrrhizic acid
    Yan Qi Ng, Chanchal Chandramouli, So Ha Ton, Khalid Abdul Kadir, Fahreen Haque, Melissa Sharmini Tamotharan
    J Mol Pathophysiol. 2012; 1(1): 3-20
    » Abstract & References » doi: 10.5455/jmp.20120221113254

  • Oxidative stress in acne vulgaris: an important therapeutic target
    Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif
    J Mol Pathophysiol. 2013; 2(1): 27-31
    » Abstract & References » doi: 10.5455/jmp.20130127102901

  • Indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase (TDO) mRNA expression in oral squamous cell carcinoma cells is actively and differentially modulated
    Nicholas P Booth, Wells Brockbank, Samuel Oh, Karl Kingsley
    J Mol Pathophysiol. 2012; 1(1): 29-36
    » Abstract & References » doi: 10.5455/jmp.20120609040915

  • Cytotoxic effects of conjugated linoleic acids on human hepatoma cancer cells (HepG2)
    Achenef Melaku, Arifah Abdul Kadir, Fauziah Othman, Goh Yong Meng, Awis Qurni Sazili
    J Mol Pathophysiol. 2012; 1(1): 43-48
    » Abstract & References » doi: 10.5455/jmp.20120127120302

  • Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis
    Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail
    J Mol Pathophysiol. 2012; 1(1): 37-42
    » Abstract & References » doi: 10.5455/jmp.20120307042400

  • Periodontitis as a risk factor for cardiovascular disease with its treatment modalities: a review
    Amit Bhardwaj, Shalu V. Bhardwaj
    J Mol Pathophysiol. 2012; 1(1): 77-83
    » Abstract & References » doi: 10.5455/jmp.20120206034643

  • A new hope in biomedical research area; Journal of Molecular Pathophysiology
    Ahmet Korkmaz, Turgut Topal
    J Mol Pathophysiol. 2012; 1(1): 1-2
    » Abstract & References » doi: 10.5455/jmp.20120604123051

  • Arterial stiffness and inflammation in patients on hemodialysis
    Vaia D. Raikou, Despina Kyriaki, John N. Boletis
    J Mol Pathophysiol. 2012; 1(1): 21-28
    » Abstract & References » doi: 10.5455/jmp.20120530044656

  • Most Downloaded
  • Prevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis
    Ertan Altaylı, Ercan Malkoc, Bilal Fırat Alp, Ahmet Korkmaz
    J Mol Pathophysiol. 2012; 1(1): 53-62
    » Abstract & References » doi: 10.5455/jmp.20120321060902

  • Oxidative stress in acne vulgaris: an important therapeutic target
    Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif
    J Mol Pathophysiol. 2013; 2(1): 27-31
    » Abstract & References » doi: 10.5455/jmp.20130127102901

  • Therapeutic potential of metals in managing diabetes mellitus: a review
    Geeta Pandey, Gyan Chand Jain, Nidhi Mathur
    J Mol Pathophysiol. 2012; 1(1): 63-76
    » Abstract & References » doi: 10.5455/jmp.20120410105457

  • A new hope in biomedical research area; Journal of Molecular Pathophysiology
    Ahmet Korkmaz, Turgut Topal
    J Mol Pathophysiol. 2012; 1(1): 1-2
    » Abstract & References » doi: 10.5455/jmp.20120604123051

  • Indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase (TDO) mRNA expression in oral squamous cell carcinoma cells is actively and differentially modulated
    Nicholas P Booth, Wells Brockbank, Samuel Oh, Karl Kingsley
    J Mol Pathophysiol. 2012; 1(1): 29-36
    » Abstract & References » doi: 10.5455/jmp.20120609040915

  • Cytotoxic effects of conjugated linoleic acids on human hepatoma cancer cells (HepG2)
    Achenef Melaku, Arifah Abdul Kadir, Fauziah Othman, Goh Yong Meng, Awis Qurni Sazili
    J Mol Pathophysiol. 2012; 1(1): 43-48
    » Abstract & References » doi: 10.5455/jmp.20120127120302

  • The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil
    MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN
    J Mol Pathophysiol. 2015; 4(1): 12-20
    » Abstract & References » doi: 10.5455/jmp.20150204115607

  • Modulation of glucose and lipid metabolism in adrenalectomised rats given glycyrrhizic acid
    Yan Qi Ng, Chanchal Chandramouli, So Ha Ton, Khalid Abdul Kadir, Fahreen Haque, Melissa Sharmini Tamotharan
    J Mol Pathophysiol. 2012; 1(1): 3-20
    » Abstract & References » doi: 10.5455/jmp.20120221113254

  • Periodontitis as a risk factor for cardiovascular disease with its treatment modalities: a review
    Amit Bhardwaj, Shalu V. Bhardwaj
    J Mol Pathophysiol. 2012; 1(1): 77-83
    » Abstract & References » doi: 10.5455/jmp.20120206034643

  • Arterial stiffness and inflammation in patients on hemodialysis
    Vaia D. Raikou, Despina Kyriaki, John N. Boletis
    J Mol Pathophysiol. 2012; 1(1): 21-28
    » Abstract & References » doi: 10.5455/jmp.20120530044656

  • Most Cited Articles
  • The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil
    MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN
    J Mol Pathophysiol. 2015; 4(1): 12-20
    » Abstract & References » doi: 10.5455/jmp.20150204115607
    Cited : 11 times [Click to see citing articles]

  • Importance of HSP70 in Livestock - at cellular level
    SMRUTI RANJAN MISHRA, TAPAN KUMAR PALAI
    J Mol Pathophysiol. 2014; 3(2): 30-32
    » Abstract & References » doi: 10.5455/jmp.20141028023220
    Cited : 8 times [Click to see citing articles]

  • Precision Cut Cancer Tissue Slices in Anti-Cancer Drug Testing
    Florian T Unger, Susanne Bentz, Jana Krüger, Cordula Rosenbrock, Janina Schaller, Katja Pursche, Annika Sprüssel, Hartmut Juhl, Kerstin A David
    J Mol Pathophysiol. 2015; 4(3): 108-121
    » Abstract & References » doi: 10.5455/jmp.20151023055556
    Cited : 7 times [Click to see citing articles]

  • Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers
    Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning
    J Mol Pathophysiol. 2015; 4(1): 6-11
    » Abstract & References » doi: 10.5455/jmp.20150127045909
    Cited : 6 times [Click to see citing articles]

  • Therapeutic potential of metals in managing diabetes mellitus: a review
    Geeta Pandey, Gyan Chand Jain, Nidhi Mathur
    J Mol Pathophysiol. 2012; 1(1): 63-76
    » Abstract & References » doi: 10.5455/jmp.20120410105457
    Cited : 5 times [Click to see citing articles]

  • Prevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis
    Ertan Altaylı, Ercan Malkoc, Bilal Fırat Alp, Ahmet Korkmaz
    J Mol Pathophysiol. 2012; 1(1): 53-62
    » Abstract & References » doi: 10.5455/jmp.20120321060902
    Cited : 5 times [Click to see citing articles]

  • The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats
    Umar Zayyanu Usman, Mahaneem Binti Mohamed
    J Mol Pathophysiol. 2015; 4(3): 103-107
    » Abstract & References » doi: 10.5455/jmp.20151022125106
    Cited : 4 times [Click to see citing articles]

  • Proximate and vitamin C analysis of wild edible plants consumed by Bodos of Assam, India
    Hwiyang Narzary1, Ananta Swargiary2 and Sanjay Basumatary3*
    J Mol Pathophysiol. 2015; 4(4): 128-133
    » Abstract & References » doi: 10.5455/jmp.20151111030040
    Cited : 4 times [Click to see citing articles]

  • Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.
    Paul L Wood, Ryan S Alexander, Cameron C Felty
    J Mol Pathophysiol. 2014; 3(3): 33-37
    » Abstract & References » doi: 10.5455/jmp.20141122032817
    Cited : 2 times [Click to see citing articles]

  • Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome
    Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina
    J Mol Pathophysiol. 2015; 4(2): 51-58
    » Abstract & References » doi: 10.5455/jmp.20150402063644
    Cited : 2 times [Click to see citing articles]