ISSN 2146-832X
 

Original Research 


Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye.

Abstract
Background/Aim: Anacardium occidentale leaves are used traditionally for the management of diabetes. This study seeks to evaluate the efficacy and safety of its continuous intake for 4 weeks in streptozotocin-induced diabetic rat model in comparison with metformin a reference drug. Materials and Methods: Thirty-six male Wistar rats (130 -145 g) were randomly divided into 6 groups of six animals each. Diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ; 50 mg/kg bw); plant extract and metformin were given orally (60 and 125 mg/kg/ bw). Results: Diabetes induction caused a significant weight loss (23.65 %) associated with a marked rise in levels of fasting blood glucose (295 mg/dl), triglycerides, total cholesterol, low-density-lipoprotein cholesterol, lipid peroxidation and serum aminotransferase activities. Besides, glucose-6-phosphate dehydrogenase (G6PD) activities, total protein concentration, high-density-lipoprotein cholesterol and tissue antioxidants (reduced glutathione; GSH, superoxide dismutase; SOD, catalase; CAT, glutathione-S-transferase; GST, Glutathione peroxidase; GPx) were diminished in STZ-induced diabetic rats. Histopathological studies also revealed various degrees of alteration in the liver diabetic rats. The effects of A. occidentale extract were compared with metformin as a reference antidiabetic drug. Treatment with A. occidentale (60 mg/kg/ bw) extract showed a significant (P<0.05) reversal effect that ameliorated the deleterious effect of STZ in all the biochemical parameters evaluated. Conclusion: Aqueous extract of A. occidentale leaves exhibits excellent antioxidant, hypoglycemic and antidiabetic effects and may be used as a therapeutic agent in the management of diabetes and its associated complications with caution as observed in histopathological studies.

Key words: A. occidentale, antihyperlipidemic, antioxidant, hypoglycaemic, metformin, streptozotocin.


 
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How to Cite this Article
Pubmed Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye. Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats. J Mol Pathophysiol. 2016; 5(4): 59-65. doi:10.5455/jmp.20160904104639


Web Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye. Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats. http://www.jmolpat.com/?mno=235563 [Access: May 21, 2019]. doi:10.5455/jmp.20160904104639


AMA (American Medical Association) Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye. Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats. J Mol Pathophysiol. 2016; 5(4): 59-65. doi:10.5455/jmp.20160904104639



Vancouver/ICMJE Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye. Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats. J Mol Pathophysiol. (2016), [cited May 21, 2019]; 5(4): 59-65. doi:10.5455/jmp.20160904104639



Harvard Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye (2016) Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats. J Mol Pathophysiol, 5 (4), 59-65. doi:10.5455/jmp.20160904104639



Turabian Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye. 2016. Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats. Journal of Molecular Pathophysiology, 5 (4), 59-65. doi:10.5455/jmp.20160904104639



Chicago Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye. "Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats." Journal of Molecular Pathophysiology 5 (2016), 59-65. doi:10.5455/jmp.20160904104639



MLA (The Modern Language Association) Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye. "Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats." Journal of Molecular Pathophysiology 5.4 (2016), 59-65. Print. doi:10.5455/jmp.20160904104639



APA (American Psychological Association) Style

Sarah Onyenibe Nwozo, Ayodeji Babatope Afolabi, Babatunji Emmanuel oyinloye (2016) Antioxidant, lipid modulating and hypoglyceamic effects of the aqueous extract of Anacardium occidentale leave in streptozotocin-induced diabetic rats. Journal of Molecular Pathophysiology, 5 (4), 59-65. doi:10.5455/jmp.20160904104639





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