ISSN 2146-832X
 

Original Research 


INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS

Shchokina Catherine, Ulanova Vera.

Abstract
Introduction. Benign prostatic hyperplasia (BPHP) is one of the most common diseases in men middle-aged and elderly. In this regard, search and study of new effective and safe medicines with prostatoprotective effect is important and actual. Methods. BPHP model reproduced the intraperitoneal administration of sulpiride male rats, 40 mg / kg for 30 days. Thick Burdock extracts at a dose of 75 mg / kg and reference drug prostaplant forte, 35 mg / kg were administered intraperitoneally in a medical mode 31 to day 52 of the study. Results. The administration of thick extract of burdock roots contributed to the reliable normalization of acid phosphatase activity in serum of animals, as it is evidenced by the absence of significant differences of indicator of the treated animals from the same indicator in the groups of animals with intact control. The administration of thick extract of burdock roots contributed to a significant inhibition of LPO processes, normalization of reduced glutathione and diene conjugates in the serum levels of thiobarbituric acid active products and reduced glutathione – in the homogenate of the prostate. The effect of the indicators mentioned above thick extract of burdock roots was not significantly inferior to the effect of the drug compared with Prostaplant Forte. Thick extract of burdock leaves inferior to thick extract of burdock roots and the reference drug by normalizing influence on the activity of acid phosphatase, the level of reduced glutathione and diene conjugates in blood serum of the experimental animals.
Conclusions. The one of the most important components of the mechanism of the prostate protective action of burdock thick extracts in benign hyperplasia of the prostate gland are their anti-inflammatory and antioxidant action wich are not inferior to the reference drug Prostaplant Forte.

Key words: thick extracts of burdock, benign prostatic hyperplasia, prostatoprotective action.


 
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How to Cite this Article
Pubmed Style

Shchokina Catherine, Ulanova Vera. INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS. J Mol Pathophysiol. 2016; 5(3): 55-58. doi:10.5455/jmp.20160601012744


Web Style

Shchokina Catherine, Ulanova Vera. INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS. http://www.jmolpat.com/?mno=224352 [Access: July 19, 2019]. doi:10.5455/jmp.20160601012744


AMA (American Medical Association) Style

Shchokina Catherine, Ulanova Vera. INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS. J Mol Pathophysiol. 2016; 5(3): 55-58. doi:10.5455/jmp.20160601012744



Vancouver/ICMJE Style

Shchokina Catherine, Ulanova Vera. INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS. J Mol Pathophysiol. (2016), [cited July 19, 2019]; 5(3): 55-58. doi:10.5455/jmp.20160601012744



Harvard Style

Shchokina Catherine, Ulanova Vera (2016) INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS. J Mol Pathophysiol, 5 (3), 55-58. doi:10.5455/jmp.20160601012744



Turabian Style

Shchokina Catherine, Ulanova Vera. 2016. INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS. Journal of Molecular Pathophysiology, 5 (3), 55-58. doi:10.5455/jmp.20160601012744



Chicago Style

Shchokina Catherine, Ulanova Vera. "INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS." Journal of Molecular Pathophysiology 5 (2016), 55-58. doi:10.5455/jmp.20160601012744



MLA (The Modern Language Association) Style

Shchokina Catherine, Ulanova Vera. "INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS." Journal of Molecular Pathophysiology 5.3 (2016), 55-58. Print. doi:10.5455/jmp.20160601012744



APA (American Psychological Association) Style

Shchokina Catherine, Ulanova Vera (2016) INVESTIGATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF BURDOCK THICK EXTRACTS ON THE MODEL OF BENIGN PROSTATIC HYPERPLASIA (BPHP) IN RATS. Journal of Molecular Pathophysiology, 5 (3), 55-58. doi:10.5455/jmp.20160601012744





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