ISSN 2146-832X
 

Original Research 


The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats

Umar Zayyanu Usman, Mahaneem Binti Mohamed.

Cited by (4)

Abstract
Background: In Africa many plants and plant products are used traditionally for the managements of diabetes mellitus or its complication. But, science based evidence on some of this product safety need to be establish. Objective: We determine the effect of the Ethanol leaves extract of Ficus glumosa on fasting blood glucose level and liver enzymes of diabetes (DM) treated rats. Methods: Thirty (30) adult rats weighing (190 220) grams of about 8 to 10 weeks of age were used for this study in a standard laboratory setting. The animals were randomly divided into six groups (n= 5 rats /group) and diabetes was induced using single dose of alloxan 150 mg/kg intraperitoneal (ip). Group 6 served as the control group receiving distilled water (5ml/kg) alone via intra-peritoneal route (ip), Group 1 (DM+Distil water), 2, 3, 4 and 5 were given treatments for 7 days. Distilled water 5ml/kg, 100mg/kg, 200mg/kg and 400mg/kg of Ficus glumosa ethanol leaves extracts respectively via intraperitoneal ip while, Group 5 (DM+Insulin) received insulin 6.0 iu/kg. Before and after treatments Fasting blood sugar levels were measured. Rats were sacrifice for the Serum liver enzymes and liver tissue for histological study after the treatments. Results: The 100mg/kg and 400mg/kg of Ethanol leave extract of Ficus glumosa significantly lowered fasting blood glucose level and 400mg/kg show elevation in liver enzymes and reveal altered hepatocyte architecture (interphase hepatitis) compared with the control group 6 and lower dosage treatment group (2 and 3). Conclusion: The results of these study reveal that Ficus glumosa possesses hypoglycemic effect and at higher dose of 400mg/kg/day have effect on liver enzymes in diabetes rat.

Key words: diabetes mellitus, liver enzymes, ficus glumosa, alloxan.


 
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This Article Cited By the following articles

A role of Ficus species in the management of diabetes mellitus: a review
Journal of Ethnopharmacology 2018; (): .

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How to Cite this Article
Pubmed Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed. The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats. J Mol Pathophysiol. 2015; 4(3): 103-107. doi:10.5455/jmp.20151022125106


Web Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed. The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats. http://www.jmolpat.com/?mno=182581 [Access: December 13, 2018]. doi:10.5455/jmp.20151022125106


AMA (American Medical Association) Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed. The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats. J Mol Pathophysiol. 2015; 4(3): 103-107. doi:10.5455/jmp.20151022125106



Vancouver/ICMJE Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed. The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats. J Mol Pathophysiol. (2015), [cited December 13, 2018]; 4(3): 103-107. doi:10.5455/jmp.20151022125106



Harvard Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed (2015) The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats. J Mol Pathophysiol, 4 (3), 103-107. doi:10.5455/jmp.20151022125106



Turabian Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed. 2015. The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats. Journal of Molecular Pathophysiology, 4 (3), 103-107. doi:10.5455/jmp.20151022125106



Chicago Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed. "The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats." Journal of Molecular Pathophysiology 4 (2015), 103-107. doi:10.5455/jmp.20151022125106



MLA (The Modern Language Association) Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed. "The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats." Journal of Molecular Pathophysiology 4.3 (2015), 103-107. Print. doi:10.5455/jmp.20151022125106



APA (American Psychological Association) Style

Umar Zayyanu Usman, Mahaneem Binti Mohamed (2015) The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats. Journal of Molecular Pathophysiology, 4 (3), 103-107. doi:10.5455/jmp.20151022125106





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