ISSN 2146-832X
 

Original Research 


Arterial stiffness and inflammation in patients on hemodialysis

Vaia D. Raikou, Despina Kyriaki, John N. Boletis.

Abstract
Objective: Arterial stiffness and inflammation may contribute to enhanced cardiovascular mortality of dialyzed patients.Our aim was the examination of the association between inflammatory factors, arterial stiffening and cardiovascular complications in patients on permanent hemodialysis modalities.
Methods: We studied 76 dialyzed patients, 47 males and 29 females.Patients were separated as regular haemodialysis (HD, n=34) and predilution haemodiafiltration (HDF, n=42) according to treatment modalities.Cardiovascular disease was defined by coronary disease (CD) and peripheral vascular disease (PVD).Arterial stiffness was measured as carotid-femoral pulse wave velocity (c-f PWV) and pulse pressure (PP) was derived.Beta2-microglobulin (beta2M), insulin, leptin, i-PTH concentrations were measured using immunoradioassay.Monocyte chemoattractant protein-1 (MCP-1) and hsCRP were measured by ELISA.Serum bicarbonate concentrations were measured using a blood gas analyzer and the ratio of cholesterol / HDL were calculated.
Results: The patients with CD and the patients with PVD presented significantly higher PP and c-fPWV, than those without CD or PVD.We observed significantly positive association between c-fPWV, PP, age and hsCRP (p<0.05), without multicollinearity.Serum bicarbonate concentrations were inversely associated with both, c-fPWV and hsCRP (r=-0.719, p=0.001 and r=-0.349, p=0.01 respectively).
hsCRP was positively correlated with leptin concentrations (r=0.283, p=0.02) and MCP-1 with the ratio chol/HDL (r=0.277, p=0.01).
Conclusions: hsCRP, as an inflammatory marker, associated with leptin concentrations, may contribute to arterial stiffness of patients on hemodialysis with cardiovascular complications.Uremic acidosis promoting the inflammation may contribute to arterial stiffness.MCP-1 was mainly associated with lipid concentrations.

Key words: pulse wave velocity; hsCRP; coronary disease; peripheral vascular disease


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Vaia D. Raikou
Articles by Despina Kyriaki
Articles by John N. Boletis
on Google
on Google Scholar
Article Statistics
 Viewed: 2710
Downloaded: 720
Cited: 0

REFERENCES
1. Guérin, Alain P; Pannier, Bruno; Marchais, Sylvain J; London, Gérard M. Cardiovascular disease in the dialysis population: prognostic significance of arterial disorders. Current Opinion in Nephrology & Hypertension 2006; 15(2):105-110. [DOI via Crossref]    [Pubmed]   
2. Peter Stenvinkel, Olof Heimbürger, Furcy Paultre, et al. Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney International 1999; 55: 1899-1911. [DOI via Crossref]    [Pubmed]   
3. R.Johnon, J.Leopold, J.Loscardo.Vascular Calcification:Pathobiological Mechanisms and clinical implications. Circulation Research 2006; 99:1044-1059. [DOI via Crossref]    [Pubmed]   
4. T. Kuragano, A. Kida, M. Furuta, et al. The Impact of &#946;2-Microglobulin Clearance on the Risk Factors of Cardiovascular Disease in Hemodialysis Patients. ASAIO Journal 2010; 56:326-332. [Pubmed]   
5. Chauveau P, Nguyen H, Combe C, et al.French Study Group for Nutrition in Dialysis.Dialyzer membrane permeability and survival in hemodialysis patients.Am J Kidney Dis.2005; 45(3):565-71. [DOI via Crossref]    [Pubmed]   
6. Daugirdas JT. Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J Am Soc Nephrol 1993; 4:1205-1213. [Pubmed]   
7. Othmane Tel H, Nemcsik J, Fekete BC,et al.Arterial stiffness in hemodialysis: which parameter to measure to predict cardiovascular mortality? Kidney Blood Press Res. 2009; 32(4):250-7. [DOI via Crossref]    [Pubmed]   
8. Asmar R, Benetos A, Topouchian J et al.Assessment of arterial distensibility by automatic pulse wave velocity measurement.Validation and clinical application studies. Hypertension 1995; 26:485-490. [DOI via Crossref]    [Pubmed]   
9. Dougirdas JT: Simplified equations for monitoring Kt/V, PCRn, eKt/V, and ePCRn. Adv Ren Replace Ther 1995; 2:295-304.
10. Friedewald WT, Levy RI, Fredrickson DS.Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6):499-502. [Pubmed]   
11. Kirschbaum B:Spurious metabolic acidosis in hemodialysis patients. Am J Kidney Dis 2000; 35:1068-1071 [DOI via Crossref]   
12. Foley RN, Murray AM, Li S, Herzog CA, McBean AM, Eggers PW, et al. Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998-1999. J Am Soc Nephrol 2005; 16:489-95. [DOI via Crossref]    [Pubmed]   
13. Gérard M. London, Jacques Blacher, Bruno Pannier et al. Arterial Wave Reflections and Survival in End-Stage Renal Failure. Hypertension. 2001; 38:434-438. [DOI via Crossref]   
14. Shoji T, Emoto M, Shinohara K, et al. Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. J Am Soc Nephrol. 2001; 12(10):2117-24. [Pubmed]   
15. Mourad JJ, Pannier B, Blacher J, et al. Creatinine clearance, pulse wave velocity, carotid compliance and essential hypertension. Kidney Int. 2001; 59(5):1834-41. [DOI via Crossref]    [Pubmed]   
16. McDermott MM, Liu K, Greenland P, et al. Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms. JAMA 2004; 292:453- 461. [DOI via Crossref]    [Pubmed]   
17. V.D.Raikou, N.Tentolouris, D.Kyriaki, A.Evaggelatou, H. Tzanatou. B2-microglobulin, pulse pressure and metabolic alterations in patients on hemodialysis. Nephron clin pract 2011; 117(3):c237-c245. 24 Yonova D. Vascular calcification and metabolic acidosis in end stage renal disease. Hippokratia. 2009; 13(3):139-40.
18. Zheng D, Cheng LT, Zhuang Z, Gu Y, Tang LJ, Wang T. Correlation between pulse wave velocity and fluid distribution in hemodialysis patients. Blood Purif. 2009; 27(3):248-52. [DOI via Crossref]    [Pubmed]   
19. Di Iorio B, Nazzaro P, Cucciniello E, Bellizzi V. Influence of haemodialysis on variability of pulse wave velocity in chronic haemodialysis patients. Nephrol Dial Transplant. 2010; 25(5):1579-83. [DOI via Crossref]    [Pubmed]   
20. Beerenhout CH, Luik AJ, Jeuken-Mertens SG, et al. Pre-dilution on-line haemofiltration vs low-flux haemodialysis: a randomized prospective study. Nephrol Dial Transplant. 2005; 20(6):1155-63. [DOI via Crossref]    [Pubmed]   
21 Yasuaki Saijo, Megumi Utsugi, Eiji Yoshioka et al. Relationship of beta2-microglobulin to arterial stiffness in Japanese subjects. Hypertension Research 2005; 28:505-511. [DOI via Crossref]    [Pubmed]   
22. Stoll G, Bendszus M. Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. Stroke 2006; 37:1923-32. [DOI via Crossref]    [Pubmed]   
23. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002; 105:1135-1143. [DOI via Crossref]    [Pubmed]   
25 Al-Aly Z. Vascular calcification in uremia: what is new and where are we going? Adv Chronic Kidney Dis. 2008; 15(4):413-9. [DOI via Crossref]    [Pubmed]   
26. Raggi P, Bellasi A, Ferramosca E, et al. Association of pulse wave velocity with vascular and valvular calcification in hemodialysis patients. Kidney Int. 2007; 71(8):802-7. [DOI via Crossref]    [Pubmed]   
27. London GM, Drueke TB. Atherosclerosis and arteriosclerosis in chronic renal failure Kidney Int. 1997; 51(6):1678-95. 33 Blai Coll, Carlos Alonso-Villaverde and Jorge Joven. Monocyte chemoattractant protein-1 and atherosclerosis: Is there room for an additional biomarker? Clin Chim Acta. 2007; 383(1-2):21-9.
28. Swarthout JT, D’Alonzo RC, Selvamurugan N, Partridge NC. Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene. 2002; 282:1-17. [DOI via Crossref]   
29 Zoccali C, Tripepi G, Cambareri F, Catalano F,et al. Adipose tissue cytokines, insulin sensitivity, inflammation, and cardiovascular outcomes in end-stage renal disease patients. J Ren Nutr. 2005; 15(1):125-30. [DOI via Crossref]   
30 Burl R Don, Laura M Rosales, Nathan W Levine, et al. Leptin is a negative acute phase protein in chronic hemodialysis patients. Kidney Intl 2001; 59:1114-1120. [DOI via Crossref]    [Pubmed]   
31 Rocco Barazzoni, Gianni Biolo, Michela Zanetti, et al. Inflammation and Adipose Tissue in Uremia. J of Renal Nutrition 2006; 16(3):204-207. [DOI via Crossref]    [Pubmed]   
32 Kengo F. Kusano, K. Nakamura, H. Kusano, et al. Significance of the Level of Monocyte Chemoattractant Protein-1 in Human Atherosclerosis. Circ J 2004; 68: 671 -676. [DOI via Crossref]   
34. Mistrík E, Bláha V, Dusilová-Sulková S, Andr&#253;s C, Kalousová M, Sobotka L. Anti-inflammatory properties of high-density lipoprotein cholesterol in chronic hemodialysis patients: impact of intervention. J Ren Nutr. 2010; 20(6):368-76. [DOI via Crossref]    [Pubmed]   
35 Ketteler M, Westenfeld R, Schlieper G, Brandenburg V. Pathogenesis of vascular calcification in dialysis patients. Clin Exp Nephrol 2005; 9:265-70. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis. Arterial stiffness and inflammation in patients on hemodialysis. J Mol Pathophysiol. 2012; 1(1): 21-28. doi:10.5455/jmp.20120530044656


Web Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis. Arterial stiffness and inflammation in patients on hemodialysis. http://www.jmolpat.com/?mno=18052 [Access: December 13, 2018]. doi:10.5455/jmp.20120530044656


AMA (American Medical Association) Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis. Arterial stiffness and inflammation in patients on hemodialysis. J Mol Pathophysiol. 2012; 1(1): 21-28. doi:10.5455/jmp.20120530044656



Vancouver/ICMJE Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis. Arterial stiffness and inflammation in patients on hemodialysis. J Mol Pathophysiol. (2012), [cited December 13, 2018]; 1(1): 21-28. doi:10.5455/jmp.20120530044656



Harvard Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis (2012) Arterial stiffness and inflammation in patients on hemodialysis. J Mol Pathophysiol, 1 (1), 21-28. doi:10.5455/jmp.20120530044656



Turabian Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis. 2012. Arterial stiffness and inflammation in patients on hemodialysis. Journal of Molecular Pathophysiology, 1 (1), 21-28. doi:10.5455/jmp.20120530044656



Chicago Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis. "Arterial stiffness and inflammation in patients on hemodialysis." Journal of Molecular Pathophysiology 1 (2012), 21-28. doi:10.5455/jmp.20120530044656



MLA (The Modern Language Association) Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis. "Arterial stiffness and inflammation in patients on hemodialysis." Journal of Molecular Pathophysiology 1.1 (2012), 21-28. Print. doi:10.5455/jmp.20120530044656



APA (American Psychological Association) Style

Vaia D. Raikou, Despina Kyriaki, John N. Boletis (2012) Arterial stiffness and inflammation in patients on hemodialysis. Journal of Molecular Pathophysiology, 1 (1), 21-28. doi:10.5455/jmp.20120530044656





Most Viewed Articles
  • Prevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis
    Ertan Altayl, Ercan Malkoc, Bilal Frat Alp, Ahmet Korkmaz
    J Mol Pathophysiol. 2012; 1(1): 53-62
    » Abstract & References » doi: 10.5455/jmp.20120321060902

  • Therapeutic potential of metals in managing diabetes mellitus: a review
    Geeta Pandey, Gyan Chand Jain, Nidhi Mathur
    J Mol Pathophysiol. 2012; 1(1): 63-76
    » Abstract & References » doi: 10.5455/jmp.20120410105457

  • Modulation of glucose and lipid metabolism in adrenalectomised rats given glycyrrhizic acid
    Yan Qi Ng, Chanchal Chandramouli, So Ha Ton, Khalid Abdul Kadir, Fahreen Haque, Melissa Sharmini Tamotharan
    J Mol Pathophysiol. 2012; 1(1): 3-20
    » Abstract & References » doi: 10.5455/jmp.20120221113254

  • Oxidative stress in acne vulgaris: an important therapeutic target
    Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif
    J Mol Pathophysiol. 2013; 2(1): 27-31
    » Abstract & References » doi: 10.5455/jmp.20130127102901

  • Indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase (TDO) mRNA expression in oral squamous cell carcinoma cells is actively and differentially modulated
    Nicholas P Booth, Wells Brockbank, Samuel Oh, Karl Kingsley
    J Mol Pathophysiol. 2012; 1(1): 29-36
    » Abstract & References » doi: 10.5455/jmp.20120609040915

  • Cytotoxic effects of conjugated linoleic acids on human hepatoma cancer cells (HepG2)
    Achenef Melaku, Arifah Abdul Kadir, Fauziah Othman, Goh Yong Meng, Awis Qurni Sazili
    J Mol Pathophysiol. 2012; 1(1): 43-48
    » Abstract & References » doi: 10.5455/jmp.20120127120302

  • Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis
    Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail
    J Mol Pathophysiol. 2012; 1(1): 37-42
    » Abstract & References » doi: 10.5455/jmp.20120307042400

  • Periodontitis as a risk factor for cardiovascular disease with its treatment modalities: a review
    Amit Bhardwaj, Shalu V. Bhardwaj
    J Mol Pathophysiol. 2012; 1(1): 77-83
    » Abstract & References » doi: 10.5455/jmp.20120206034643

  • A new hope in biomedical research area; Journal of Molecular Pathophysiology
    Ahmet Korkmaz, Turgut Topal
    J Mol Pathophysiol. 2012; 1(1): 1-2
    » Abstract & References » doi: 10.5455/jmp.20120604123051

  • Arterial stiffness and inflammation in patients on hemodialysis
    Vaia D. Raikou, Despina Kyriaki, John N. Boletis
    J Mol Pathophysiol. 2012; 1(1): 21-28
    » Abstract & References » doi: 10.5455/jmp.20120530044656

  • Most Downloaded
  • Prevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis
    Ertan Altayl, Ercan Malkoc, Bilal Frat Alp, Ahmet Korkmaz
    J Mol Pathophysiol. 2012; 1(1): 53-62
    » Abstract & References » doi: 10.5455/jmp.20120321060902

  • Oxidative stress in acne vulgaris: an important therapeutic target
    Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Ahmed R. Abu Raghif
    J Mol Pathophysiol. 2013; 2(1): 27-31
    » Abstract & References » doi: 10.5455/jmp.20130127102901

  • Therapeutic potential of metals in managing diabetes mellitus: a review
    Geeta Pandey, Gyan Chand Jain, Nidhi Mathur
    J Mol Pathophysiol. 2012; 1(1): 63-76
    » Abstract & References » doi: 10.5455/jmp.20120410105457

  • A new hope in biomedical research area; Journal of Molecular Pathophysiology
    Ahmet Korkmaz, Turgut Topal
    J Mol Pathophysiol. 2012; 1(1): 1-2
    » Abstract & References » doi: 10.5455/jmp.20120604123051

  • Indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase (TDO) mRNA expression in oral squamous cell carcinoma cells is actively and differentially modulated
    Nicholas P Booth, Wells Brockbank, Samuel Oh, Karl Kingsley
    J Mol Pathophysiol. 2012; 1(1): 29-36
    » Abstract & References » doi: 10.5455/jmp.20120609040915

  • Cytotoxic effects of conjugated linoleic acids on human hepatoma cancer cells (HepG2)
    Achenef Melaku, Arifah Abdul Kadir, Fauziah Othman, Goh Yong Meng, Awis Qurni Sazili
    J Mol Pathophysiol. 2012; 1(1): 43-48
    » Abstract & References » doi: 10.5455/jmp.20120127120302

  • The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil
    MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN
    J Mol Pathophysiol. 2015; 4(1): 12-20
    » Abstract & References » doi: 10.5455/jmp.20150204115607

  • Modulation of glucose and lipid metabolism in adrenalectomised rats given glycyrrhizic acid
    Yan Qi Ng, Chanchal Chandramouli, So Ha Ton, Khalid Abdul Kadir, Fahreen Haque, Melissa Sharmini Tamotharan
    J Mol Pathophysiol. 2012; 1(1): 3-20
    » Abstract & References » doi: 10.5455/jmp.20120221113254

  • Periodontitis as a risk factor for cardiovascular disease with its treatment modalities: a review
    Amit Bhardwaj, Shalu V. Bhardwaj
    J Mol Pathophysiol. 2012; 1(1): 77-83
    » Abstract & References » doi: 10.5455/jmp.20120206034643

  • Arterial stiffness and inflammation in patients on hemodialysis
    Vaia D. Raikou, Despina Kyriaki, John N. Boletis
    J Mol Pathophysiol. 2012; 1(1): 21-28
    » Abstract & References » doi: 10.5455/jmp.20120530044656

  • Most Cited Articles
  • The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil
    MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN
    J Mol Pathophysiol. 2015; 4(1): 12-20
    » Abstract & References » doi: 10.5455/jmp.20150204115607
    Cited : 11 times [Click to see citing articles]

  • Importance of HSP70 in Livestock - at cellular level
    SMRUTI RANJAN MISHRA, TAPAN KUMAR PALAI
    J Mol Pathophysiol. 2014; 3(2): 30-32
    » Abstract & References » doi: 10.5455/jmp.20141028023220
    Cited : 8 times [Click to see citing articles]

  • Precision Cut Cancer Tissue Slices in Anti-Cancer Drug Testing
    Florian T Unger, Susanne Bentz, Jana Krger, Cordula Rosenbrock, Janina Schaller, Katja Pursche, Annika Sprssel, Hartmut Juhl, Kerstin A David
    J Mol Pathophysiol. 2015; 4(3): 108-121
    » Abstract & References » doi: 10.5455/jmp.20151023055556
    Cited : 7 times [Click to see citing articles]

  • Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers
    Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning
    J Mol Pathophysiol. 2015; 4(1): 6-11
    » Abstract & References » doi: 10.5455/jmp.20150127045909
    Cited : 6 times [Click to see citing articles]

  • Therapeutic potential of metals in managing diabetes mellitus: a review
    Geeta Pandey, Gyan Chand Jain, Nidhi Mathur
    J Mol Pathophysiol. 2012; 1(1): 63-76
    » Abstract & References » doi: 10.5455/jmp.20120410105457
    Cited : 5 times [Click to see citing articles]

  • Prevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis
    Ertan Altayl, Ercan Malkoc, Bilal Frat Alp, Ahmet Korkmaz
    J Mol Pathophysiol. 2012; 1(1): 53-62
    » Abstract & References » doi: 10.5455/jmp.20120321060902
    Cited : 5 times [Click to see citing articles]

  • The effect of ethanol extract of Nigerian ficus glumosa leaf on liver function in Diabetic rats
    Umar Zayyanu Usman, Mahaneem Binti Mohamed
    J Mol Pathophysiol. 2015; 4(3): 103-107
    » Abstract & References » doi: 10.5455/jmp.20151022125106
    Cited : 4 times [Click to see citing articles]

  • Proximate and vitamin C analysis of wild edible plants consumed by Bodos of Assam, India
    Hwiyang Narzary1, Ananta Swargiary2 and Sanjay Basumatary3*
    J Mol Pathophysiol. 2015; 4(4): 128-133
    » Abstract & References » doi: 10.5455/jmp.20151111030040
    Cited : 4 times [Click to see citing articles]

  • Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.
    Paul L Wood, Ryan S Alexander, Cameron C Felty
    J Mol Pathophysiol. 2014; 3(3): 33-37
    » Abstract & References » doi: 10.5455/jmp.20141122032817
    Cited : 2 times [Click to see citing articles]

  • Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome
    Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina
    J Mol Pathophysiol. 2015; 4(2): 51-58
    » Abstract & References » doi: 10.5455/jmp.20150402063644
    Cited : 2 times [Click to see citing articles]