ISSN 2146-832X
 

Original Research 


Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina.

Cited by (2)

Abstract
Metabolic syndrome (MetS) may have an adverse impact on cardiovascular events in unselected populations. However, the role of MetS in chronic heart failure (CHF) subjects remains controversial. Endothelial-derived microparticles (EMPs) may play a pivotal role in cell-to-cell cooperation, effects negatively on tissue reparation, and mediates vascular function. Pattern of circulating EMPs probably reflects imbalance between endothelial cell injury and endothelial repair. The aim of the study: to investigate an inflammatory pattern of circulating EMPs in MetS patients with CHF.
Methods: The study retrospectively evolved 101 patients with MetS (54 subjects with CHF and 47 patients without CHF) without documented coronary artery stenosis > 50% at least of one artery and 35 healthy volunteers. Biomarkers were measured at baseline of the study. Circulating EMPs were phenotyped by flow cytometry technique.
Results: We found CD62E+ EMPs and CD62E+ to CD31+/annexin V+ ratio were elevated in healthy persons when compared with MetS patients. CD62E+ to CD31+/annexin V+ ratio was found to be higher in the MetS patients without CHF compared with MetS patients with CHF. Using multiple linear regression analysis, independent impact of BMI, NT-proBNP, osteoprotegerin and hs-CRP on decreased CD62E+ to CD31+/annexin V+ ratio was found. We found that adding of combination of inflammatory biomarkers (hs-CRP, osteoprotegerin and NT-proBNP) to the based model (BMI) improved the relative integrated discrimination indices by 11.4% for decreased CD62E+ to CD31+/annexin V+ ratio.
In conclusion, we found that biomarkers of biomechanical stress (NT-proBNP) and inflammation (hs-CRP, osteoprotegerin) remain statistically significant predictors for decreased CD62E+ to CD31+/annexin V+ ratio in MetS patients with CHF.

Key words: Chronic heart failure; metabolic syndrome; circulating endothelial-derived microparticles; cardiovascular risk factors.


 
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This Article Cited By the following articles

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Pattern of circulating microparticles in chronic heart failure patients with metabolic syndrome: Relevance to neurohumoral and inflammatory activation
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How to Cite this Article
Pubmed Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina. Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome. J Mol Pathophysiol. 2015; 4(2): 51-58. doi:10.5455/jmp.20150402063644


Web Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina. Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome. http://www.jmolpat.com/?mno=180345 [Access: December 13, 2018]. doi:10.5455/jmp.20150402063644


AMA (American Medical Association) Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina. Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome. J Mol Pathophysiol. 2015; 4(2): 51-58. doi:10.5455/jmp.20150402063644



Vancouver/ICMJE Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina. Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome. J Mol Pathophysiol. (2015), [cited December 13, 2018]; 4(2): 51-58. doi:10.5455/jmp.20150402063644



Harvard Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina (2015) Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome. J Mol Pathophysiol, 4 (2), 51-58. doi:10.5455/jmp.20150402063644



Turabian Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina. 2015. Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome. Journal of Molecular Pathophysiology, 4 (2), 51-58. doi:10.5455/jmp.20150402063644



Chicago Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina. "Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome." Journal of Molecular Pathophysiology 4 (2015), 51-58. doi:10.5455/jmp.20150402063644



MLA (The Modern Language Association) Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina. "Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome." Journal of Molecular Pathophysiology 4.2 (2015), 51-58. Print. doi:10.5455/jmp.20150402063644



APA (American Psychological Association) Style

Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina (2015) Inflammatory phenotype of circulating endothelial-derived microparticles in chronic heart failure patients with metabolic syndrome. Journal of Molecular Pathophysiology, 4 (2), 51-58. doi:10.5455/jmp.20150402063644





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