ISSN 2146-832X
 

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The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN.

Cited by (11)

Abstract
Aim: Geopropolis is produced by stingless bees from resinous materials of plants, adding salivary secretions, wax, soil, and has been used in folk medicine for the treatment of respiratory diseases and dermatoses. Therefore, it is important to study its antibacterial, antitumor and immunomodulatory properties to confirm the ethnopharmacological applications. This work aimed to evaluate its chemical composition, and its antimicrobial, anti-tumoral and immunomodulatory activities. Methods: Geopropolis composition was investigated using GC-MS analysis. Antibacterial tests were performed to determine the minimum inhibitory concentration. HEp-2 cells viability was determined by the reduction of MTT, and cytokine production by human monocytes was determined by ELISA. Results: The major constituents of geopropolis compounds were carbohydrates and their derivatives, triterpenes, anacardic acid, alkylresorcinols, and sugar alcohols. Geopropolis alone showed no antibacterial activity against Staphylococcus aureus and Escherichia coli, but its combination with chloramphenicol exerted a greater action against S. aureus than chloramphenicol alone. Geopropolis exhibited a cytostatic action toward human laryngeal epidermoid carcinoma cells and stimulated tumor necrosis factor alpha and interleukin-10 production by human monocytes, showing an activator profile for human monocytes. Conclusion: The synergistic effect of geopropolis and chloramphenicol deserves further investigation due to bacterial resistance to antibiotics. Geopropolis also displayed antitumoral and immunomodulatory activity, and its biological properties may be due to triterpenes - one of its major chemical constituents.

Key words: Geopropolis Chemical composition Pharmacological activities HEp-2 cells Cytokine


 
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How to Cite this Article
Pubmed Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN. The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil. J Mol Pathophysiol. 2015; 4(1): 12-20. doi:10.5455/jmp.20150204115607


Web Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN. The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil. http://www.jmolpat.com/?mno=177399 [Access: December 13, 2018]. doi:10.5455/jmp.20150204115607


AMA (American Medical Association) Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN. The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil. J Mol Pathophysiol. 2015; 4(1): 12-20. doi:10.5455/jmp.20150204115607



Vancouver/ICMJE Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN. The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil. J Mol Pathophysiol. (2015), [cited December 13, 2018]; 4(1): 12-20. doi:10.5455/jmp.20150204115607



Harvard Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN (2015) The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil. J Mol Pathophysiol, 4 (1), 12-20. doi:10.5455/jmp.20150204115607



Turabian Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN. 2015. The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil. Journal of Molecular Pathophysiology, 4 (1), 12-20. doi:10.5455/jmp.20150204115607



Chicago Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN. "The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil." Journal of Molecular Pathophysiology 4 (2015), 12-20. doi:10.5455/jmp.20150204115607



MLA (The Modern Language Association) Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN. "The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil." Journal of Molecular Pathophysiology 4.1 (2015), 12-20. Print. doi:10.5455/jmp.20150204115607



APA (American Psychological Association) Style

MARIA ARAUJO, MICHELLE BUFALO, BRUNO CONTI, ARY FERNANDES JR., BORYANA TRUSHEVA, VASSYA BANKOVA, JOSE SFORCIN (2015) The chemical composition and pharmacological activities of geopropolis produced by Melipona fasciculata Smith in northeast Brazil. Journal of Molecular Pathophysiology, 4 (1), 12-20. doi:10.5455/jmp.20150204115607





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