Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning

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J Mol Pathophysiol. 2015; 4(1): 6-11

doi: 10.5455/jmp.20150127045909

Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning.

Cited by (6)

Abstract
Background: One of the primary causes of obesity-associated disease is the habitual consumption of a high-fat, high-calorie diet. The purpose of this study was to determine the effect of consumption of a high-fat, high-calorie breakfast on consecutive days on the area under the curve (AUC) for 22 emerging cardiovascular disease (CVD) biomarkers in young women (N=8). Material and Methods: Subjects consumed a high-fat (70% of daily calories, 100% of daily fat) breakfast meal on two consecutive days. Blood samples were collected pre-meal, 1h, 2h, 3h, 4h, and 5h post-meal. Cholesterol, triglycerides, and glucose were measured using an enzymatic assay. CVD biomarkers were analyzed simultaneously in serum using a multiplex method and AUC was calculated separately for each biomarker on each day. A paired t-test with significance set at P<0.05 was used to compare the outcomes. Results: We observed similar AUC for total cholesterol, triglycerides, and glucose between the 1st and 2nd day of the meal. In contrast, endocan-1, CXCL6, CXCL16, fibrinogen, placental growth factor, and adipsin exhibited statistically greater AUC on the 2nd compared to the first day. Conclusion: Further evaluation of these targets, revealed that the largest changes were in endocan-1, CXCL6, and CXCL16, which have been linked to atherogenesis. These findings support the notion that chronic CVD risk may result from the cumulative effects associated with eating high-fat foods on a habitual basis.

Key words: Inflammation, Nutrition, Meal-Response, Multiplex, Post-Prandial

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How to Cite this Article

Pubmed Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning. Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers. J Mol Pathophysiol. 2015; 4(1): 6-11. doi:10.5455/jmp.20150127045909

Web Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning. Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers. http://www.jmolpat.com/?mno=176666 [Access: February 15, 2020]. doi:10.5455/jmp.20150127045909

AMA (American Medical Association) Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning. Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers. J Mol Pathophysiol. 2015; 4(1): 6-11. doi:10.5455/jmp.20150127045909

Vancouver/ICMJE Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning. Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers. J Mol Pathophysiol. (2015), [cited February 15, 2020]; 4(1): 6-11. doi:10.5455/jmp.20150127045909

Harvard Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning (2015) Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers. J Mol Pathophysiol, 4 (1), 6-11. doi:10.5455/jmp.20150127045909

Turabian Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning. 2015. Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers. Journal of Molecular Pathophysiology, 4 (1), 6-11. doi:10.5455/jmp.20150127045909

Chicago Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning. "Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers." Journal of Molecular Pathophysiology 4 (2015), 6-11. doi:10.5455/jmp.20150127045909

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Brian K McFarlin, Katie C Carpenter, Adam S Venable, Eric A Prado, Andie L Henning (2015) Consumption of a High-Fat Breakfast on Consecutive Days Alters the Area-under-the-curve for Selected CVD Biomarkers. Journal of Molecular Pathophysiology, 4 (1), 6-11. doi:10.5455/jmp.20150127045909