ISSN 2146-832X
 

Original Research 


Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.

Paul L Wood, Ryan S Alexander, Cameron C Felty.

Cited by (2)

Abstract
ABSTRACT
Aim: Disulfiram has rare serious neurotoxicities including optic neuropathy, peripheral neuropathy and basal ganglia lesions. Since the mechanism of these toxicities is not understood, we undertook a lipidomics analysis of the effects of disulfiram on human lymphoblasts. Materials and Methods: Human lymphoblasts were incubated with disulfiram and the cellular lipidome was analyzed by ESI-high resolution mass spectrometry. Results: Disulfiram decreased the levels of a large number of glycerophospholipids, sphingolipids, and diacylglycerols. Conclusion: Disulfiram has dramatic effects on the levels of structural lipids in human lymphoblasts. These actions may explain the neurotoxicities of this drug in humans.

Key words: disulfiram, neurotoxicity, lipidomics, lymphoblasts


 
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How to Cite this Article
Pubmed Style

Paul L Wood, Ryan S Alexander, Cameron C Felty. Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.. J Mol Pathophysiol. 2014; 3(3): 33-37. doi:10.5455/jmp.20141122032817


Web Style

Paul L Wood, Ryan S Alexander, Cameron C Felty. Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.. http://www.jmolpat.com/?mno=173167 [Access: December 13, 2018]. doi:10.5455/jmp.20141122032817


AMA (American Medical Association) Style

Paul L Wood, Ryan S Alexander, Cameron C Felty. Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.. J Mol Pathophysiol. 2014; 3(3): 33-37. doi:10.5455/jmp.20141122032817



Vancouver/ICMJE Style

Paul L Wood, Ryan S Alexander, Cameron C Felty. Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.. J Mol Pathophysiol. (2014), [cited December 13, 2018]; 3(3): 33-37. doi:10.5455/jmp.20141122032817



Harvard Style

Paul L Wood, Ryan S Alexander, Cameron C Felty (2014) Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.. J Mol Pathophysiol, 3 (3), 33-37. doi:10.5455/jmp.20141122032817



Turabian Style

Paul L Wood, Ryan S Alexander, Cameron C Felty. 2014. Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.. Journal of Molecular Pathophysiology, 3 (3), 33-37. doi:10.5455/jmp.20141122032817



Chicago Style

Paul L Wood, Ryan S Alexander, Cameron C Felty. "Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.." Journal of Molecular Pathophysiology 3 (2014), 33-37. doi:10.5455/jmp.20141122032817



MLA (The Modern Language Association) Style

Paul L Wood, Ryan S Alexander, Cameron C Felty. "Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.." Journal of Molecular Pathophysiology 3.3 (2014), 33-37. Print. doi:10.5455/jmp.20141122032817



APA (American Psychological Association) Style

Paul L Wood, Ryan S Alexander, Cameron C Felty (2014) Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.. Journal of Molecular Pathophysiology, 3 (3), 33-37. doi:10.5455/jmp.20141122032817





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