ISSN 2146-832X
 

Original Research 


Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail.

Cited by (1)

Abstract
Background: Toxoplasmic retinochoroiditis is the most common cause of posterior uveitis (intraocular inflammatory syndrome) in immunocompetent patients. Leucocytes- endothelial adhesion is an early step in many inflammatory disorders that mediated by endothelial cell adhesion molecules. Intercellular adhesion molecule-1 (ICAM-1) was reported to be upregulated in retinal inflammatory diseases.
Objective: The present study aimed to determine the frequency of T. gondii infection among patients presented with retinal inflammatory lesions and also, determine whether the ICAM-1 implicated in the pathogenesis of toxoplasmic retinochoroiditis.
Methods: Forty four patients with retinal inflammatory lesions, 44 healthy controls without any ocular manifestation were subjected to determine anti- Toxoplasma IgG antibodies seropositivity and sICAM-1 serum level using the commercially available enzyme linked immunosorbent assay kits.
Results: Our results showed that the frequancy of anti- Toxoplasma IgG antibodies among ocular group (59.1%) was high statistically significant than that in healthy controls group (18.2%). Regarding the level of the sICAM-1 in ocular Toxo positive subgroup, there was significantly higher level compared to ocular Toxo negative subgroup and healthy controls Toxo positive subgroup. Also, it was significantly higher than healthy controls Toxo negative subgroup. Concerning the healthy controls group, there was significantly higher level of sICAM-1 in Toxo positive subgroup compared to Toxo negative subgroup.
Conclusion: our findings suggested that ICAM-1 expression might be implicated in the pathogenesis of toxoplasmic retinochoroiditis whereas sICAM-1 could be a good marker reflecting disease severity.

Key words: Toxoplasma gondii, retinochoroiditis, uveitis, pathogenesis, anti-T. gondii IgG, sICAM-1, enzyme linked immunosorbent assay.


 
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REFERENCES
1. Smith JR, Cunningham ET. Atypical presentations of ocular toxoplasmosis. Current Opinions in Ophthalmology 2002; 13(6): 387-392. [DOI via Crossref]   
2. Bornand JE, Gottrau Pde. Uveitis: is ocular toxoplasmosis only a clinical diagnosis? Ophthalmologica 1997; 211:87-89. [DOI via Crossref]    [Pubmed]   
3. Montoya JG, Remington JS. Toxoplasmic chorioretinitis in the setting of acute acquired toxoplasmosis. Clin Infect Dis 1996; 23:277-282. [DOI via Crossref]   
4. Vallochi AL, Goldberg AC, Falcai A, Ramasawmy R, Kalil J, Silveira C, Belfort Jr R, Rizzo LV. Molecular markers of susceptibility to ocular toxoplasmosis, host and guest behaving badly. Clin Ophthalmol 2008; 2:837-48. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. Commodaro AG, Belfort RN, Rizzo LV, Muccioli C, Silveira C, Burnier Jr MN, Belfort Jr R. Ocular toxoplasmosis: an update and review of the literature. Mem Inst Oswaldo Cruz 2009; 104: 345-350. [DOI via Crossref]    [Pubmed]   
6. Jabs DA. Ocular toxoplasmosis. Int Ophthalmol Clin 1990; 30:264-270. [DOI via Crossref]    [Pubmed]   
7. Holland GN. Ocular toxoplasmosis: new directions for clinical investigation. Ocul Immunol Inflamm 2000; 8:1-7. [Pubmed]   
8. Antoniazzi E, Guagliano R, Meroni V, Pezzotta S, Bianchi PE. Ocular impairment of toxoplasmosis. Parassitologia 2008; 50(1-2):35-6. [Pubmed]   
9. Zamora DO, Rosenbaum JT, Smith JR. Invasion of human retinal vascular endothelial cells by Toxoplasma gondii tachyzoites. Br J Ophthalmol 2008; 92:852-855 [DOI via Crossref]    [Pubmed]   
10. Bloom S, Fleming K, Chapman R. Adhesion molecule expression in primary sclerosing cholangitis and primary biliary cirrhosis. Gut 1995; 36:604. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
11. Carlos TM, Harlan JM. Leucocyte-endothelial adhesion molecules. Blood 1994; 84:2068-2101. [Pubmed]   
12. De Vos AF, Hoekzema R, Kijlstra A. Cytokines and uveitis, a review. Curr Eye Res 1992; 11:581-597. [DOI via Crossref]    [Pubmed]   
13. Wakefield D, Lloyd A. The role of cytokines in the pathogenesis of inflammatory eye disease. Cytokine 1992; 4:1-5. [DOI via Crossref]   
14. Hughes JM, Brink A, Witmer AN, Hanraads-de Riemer M, Klaassen I, Schlingemann RO. Vascular leucocyte adhesion molecules unaltered in the human retina in diabetes. Br J Ophthalmol 2004; 88:566-72. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
15. Mullins RF, Skeie JM, Malone EA, Kuehn MH. Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina. Mol Vis 2006; 12:224-35. [Pubmed]   
16. Klok A-M, Luyendijk L, Zaal MJW, Rothova A, Kijlstra A. Soluble ICAM-1 serum levels in patients with intermediate uveitis. Br J Ophthalmol 1999; 83:847-851 [DOI via Crossref]   
17. Portillo JAC, Okenka G, Kern TS, Subauste CS. Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry. Molecular Vision 2009; 15:1383-1389 [Pubmed]    [PMC Free Fulltext]   
18. Nagineni CN, Detrick B, Hooks JJ. Toxoplasma gondii infection induces gene expression and secretion of interleukin 1(IL-1), IL-6, granulocyte-macrophage colony, and intracellular adhesion molecule-1 by human retinal pigment epithelial cells. Infect Immun 2000; 68(1): 407-410. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
19. Champagne B, Tremblay P, Cantin A, St Pierre Y Proteolytic cleavage of ICAM-1 by human neutrophils elastase. J Immunol 1998; 161: 6398-6405. [Pubmed]   
20. Seth R, Raymond FD, Makgoba MW. Circulating ICAM-1 isoforms : diagnostic prospects for inflammatory and immune disorders. Lancet 1991; 338:83-84. [DOI via Crossref]   
21. Rothlein R, Mainolfi EA, Czakowski M, Marlin SD. A form of circulating ICAM-1 in human serum. J Immunol 1991; 147: 3788-3793. [Pubmed]   
22. Austgulen R, Lien E, Vince G, Redman CW. Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia. Eur J Obstet Gynecol Reprod Biol 1997; 71:53-58. [DOI via Crossref]   
23. Arocker-Mettinger E, Steurer-Georgiew L, Steurer M. Circulating ICAM-1 levels in serum of uveitis patients. Curr Eye Res 1992; 11:161-6. [DOI via Crossref]    [Pubmed]   
24. De Boer JH, Van Hren MAC, Vries-Knoppert WA, Baarsma GS, Jong FJ, Postema AJ Radmakers JM, Kijlstra A. Analysis of IL-6 levels in human vitreous fluid obtained from uveitis patients, patients with proliferative intraocular disorders. Curr Eye Res 1992; 11:181-186. [DOI via Crossref]    [Pubmed]   
25. Palmer HE, Zaman AG, Ellis BA. Longitudinal analysis of soluble intercellular adhesion molecule 1 in retinal vasculitis patients. Eur J Clin Invest 1996; 26:686-91. [DOI via Crossref]    [Pubmed]   
26. Zaman AG, Edelsten C, Stanford M R, Grahamt EM, Ellis BA, Direskeneli H, D'cruz DP, Hughes GRV, Dumonde DC, GR Wallace. Soluble intercellular adhesion molecule-1 (sICAM-1) as a marker of disease relapse in idiopathic uveoretinitis. Clin Exp Immunol 1994; 95:60-5. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
27. Delair E, Creuzet C, Dupouy-Camet J, Roisin MP. In vitro effect of TNF-α and IFN-γ in retinal cell infection with Toxoplasma gondii. Investigative Ophthalmology & Visual Science 2009; 50(4): 1754-1760. [DOI via Crossref]    [Pubmed]   
28. Barragan A, Sibley LD. Migration of Toxoplasma gondii across biological barriers. Trends Microbiol 2003; 11: 426-430. [DOI via Crossref]   
29. Roberts F, McLeod R. Pathogenesis of toxoplasmic retinochoroiditis. Parasitology Today 1999; 15(2): 51-57. [DOI via Crossref]   
30. Pfaff AW, Georges S, Abou-Bacar A, Letscher-Bru V, Klein J, Mousli M, Candolfi E. Toxoplasma gondii regulates ICAM-1 mediated monocyte adhesion to trophoblasts. Immunology and Cell Biology 2005; 83: 483-489. [DOI via Crossref]    [Pubmed]   
31. Friedman AH. Uveitis affecting the retina and posterior segment. In W R Freeman (ed.), Atlas of the retinal diseases and therapy. Raven Press, New York, NY, p. 37-70, 1993.
32. Nagineni CN, Pardhasaradhi K, Martins MC, Detrick B, Hooks JJ. Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells. Infection and Immunity, 1996a; 64 (10): 4188-4196. [Pubmed]    [PMC Free Fulltext]   
33. Heidenkummer HP, Kampick A. Intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) expression in human epiretinal membranes. Graefe’s Arch. Clin Exp Ophthalmol 1992; 230:483-487. [DOI via Crossref]   
34. Denkers EY, Gazzinelli RT. Regulation and function of T-cell mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 1998; 11: 569-88. [Pubmed]    [PMC Free Fulltext]   
35. Nagineni CN, Kutty RK, Detrick B, Hooks JJ. Inflammatory cytokines induce intercellular adhesion molecule-1 (ICAM-1) mRNA synthesis and protein secretion by human retinal pigment epithelial cell cultures. Cytokine 1996b; 8(8):622- 630. [DOI via Crossref]    [Pubmed]   
36. Barragan A, Brossier F, Sibley LD. Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2. Cell Microbiol 2005; 7: 561-8. [DOI via Crossref]    [Pubmed]   
37. Holland GN. Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease. Am J Ophthalmol 2003; 136(6):973-988. [DOI via Crossref]    [Pubmed]   
38. Glasner PD, Silveira C, Kruszon-Moran D, Martins MC, Burnier Júnior M, Silveira S. An unusually high prevalence of ocular toxoplasmosis in southern Brazil. Am J Ophthalmol 1992; 114(2):136-44. [Pubmed]   
39. Lum F, Jones JL, Holland GN, Liesegang T J. Survey of ophthalmologists about ocular toxoplasmosis. Am J Ophthalmol 2005; 140: (4) 724.e1- 724.e9.
40. Brown CR, Hunter CA, Estes RG. Beckmann E, Forman J, David C, Remington JS, Mcleod R. Definitive identification of a gene that confers resistance against Toxoplasma cyst burden and encephalitis. Immunology 1995; 85: 419-428. [Pubmed]    [PMC Free Fulltext]   
41. Sundar P, Mahadevan A, Jayshree RS, Subbakrishna DK, Shankar SK. Toxoplasma seroprevalence in healthy voluntary blood donors from urban Karnataka Indian J Med Res 2007; 126: 50-55. [Pubmed]   
42. Joshi YR, Vyas S, Joshi KR. Seroprevalence of toxoplasmosis in Jodhpur, India. J Commun Dis 1998; 30: 32-7. [Pubmed]   
43. Silveira C, Vallochi AL, Rodrigues da Silva U, Muccioli C, Holland GN, Nussenblatt RB, Belfort R, Rizzo LV. Toxoplasma gondii in the peripheral blood of patients with acute and chronic toxoplasmosis. Br J Ophthalmol 2011; 95:396e400.
44. Whitcup SM, Chan CC, Li Q, Nussenblatt RB. Expression of cell adhesion molecules in posterior uveitis. Arch Ophthalmol 1992; 110:662- 666. [DOI via Crossref]    [Pubmed]   
45. Duguid IGM, Boyd AW, Mandel TE. Adhesion molecules are expressed in the human retina and choroid. Curr Eye Res 1992; 11:153-9. [DOI via Crossref]    [Pubmed]   
46. Shelton MD, Kern TS, Mieyal JJ. Glutaredoxin regulates nuclear factor kappa-B and intracellular adhesion molecule in Muller cells: model of diabetic retinopathy. J Biol Chem 2007; 282:12467-74. [DOI via Crossref]    [Pubmed]   
47. Derouin F, Garin YJF. Toxoplasma gondii : blood and tissue kinetics during acute and chronic infection in mice. Exp Parasitol 1991; 73:460-468. [DOI via Crossref]   
48. Lukas NW, Chensue SW, Strieter RM. Warmington K, Kunkel SL. Inflammatory granuloma formation is mediated by TNF-alpha inducible intracellular adhesion molecule-1. J Immunol 1994; 152: 5883-5889.

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How to Cite this Article
Pubmed Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail. Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis. J Mol Pathophysiol. 2012; 1(1): 37-42. doi:10.5455/jmp.20120307042400


Web Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail. Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis. http://www.jmolpat.com/?mno=13987 [Access: December 13, 2018]. doi:10.5455/jmp.20120307042400


AMA (American Medical Association) Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail. Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis. J Mol Pathophysiol. 2012; 1(1): 37-42. doi:10.5455/jmp.20120307042400



Vancouver/ICMJE Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail. Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis. J Mol Pathophysiol. (2012), [cited December 13, 2018]; 1(1): 37-42. doi:10.5455/jmp.20120307042400



Harvard Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail (2012) Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis. J Mol Pathophysiol, 1 (1), 37-42. doi:10.5455/jmp.20120307042400



Turabian Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail. 2012. Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis. Journal of Molecular Pathophysiology, 1 (1), 37-42. doi:10.5455/jmp.20120307042400



Chicago Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail. "Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis." Journal of Molecular Pathophysiology 1 (2012), 37-42. doi:10.5455/jmp.20120307042400



MLA (The Modern Language Association) Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail. "Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis." Journal of Molecular Pathophysiology 1.1 (2012), 37-42. Print. doi:10.5455/jmp.20120307042400



APA (American Psychological Association) Style

Nagwa Mostafa El-Sayed, Khadiga Ahmed Ismail (2012) Role of intracellular adhesion molecules-1 (ICAM-1) in the pathogenesis of toxoplasmic retinochoroiditis. Journal of Molecular Pathophysiology, 1 (1), 37-42. doi:10.5455/jmp.20120307042400





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